noun
a condition in which the walls of the arteries become thicker and less flexible, leading to restricted blood flow
preposition
a word governing, and usually preceding, a noun or pronoun and expressing a relation to another word or element in the clause
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Hardening of the arteries, also known as atherosclerosis, is a serious medical condition that can lead to heart disease.
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My doctor told me I need to watch my cholesterol to prevent hardening of the arteries.
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Eating all that junk food is just asking for a case of hardening of the arteries.
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The lack of communication in their relationship was like a slow hardening of the arteries, leading to eventual breakdown.