verb
to release or set free
adverb
freely or without restraint
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During the team-building retreat, the participants were encouraged to let loose and have fun.
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At the party last night, everyone let loose and danced until the early hours of the morning.
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After the exams were over, we decided to let loose and hit up the club.
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When she finally let loose and shared her true feelings, it was a weight off her shoulders.