noun
a drug or substance that reduces functional or nervous activity
adjective
relating to or causing a decrease in functional or nervous activity
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Alcohol is a central nervous system depressant that slows down brain function.
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I heard that Xanax is a depressant, so be careful with it.
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I can't believe he's still taking those downers, they're such strong depressants.
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The rainy weather has a depressant effect on my mood.