noun
lack of knowledge or experience with something
adjective
unfamiliar
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Due to her unfamiliarity with the new software, she struggled to complete the task efficiently.
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I felt a sense of unfamiliarity when I walked into the party and didn't recognize anyone.
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The unfamiliarity of the neighborhood made me feel a bit out of place.
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The unfamiliarity of the situation was like being lost in a maze with no map.