noun
a feeling of annoyance or anger caused by something that is bothersome or unpleasant
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The constant noise from the construction site caused a great deal of irritation among the residents.
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Her constant nagging is starting to become a source of irritation for me.
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I can't stand that guy, he's such an irritation.
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The unresolved issue between them was like a lingering irritation that never seemed to go away.