noun
a reversal or check in progress; a change from better to worse
verb
to slow the progress of; hinder
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The project faced a major setback when the main supplier backed out at the last minute.
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I had a setback with my car when the tire blew out on the highway.
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I experienced a setback when I failed my driving test for the third time.
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After the setback of losing her job, she decided to start her own business.