noun
an acute, highly contagious, and often fatal infectious disease caused by the variola virus and characterized by a high fever and a distinctive rash
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Smallpox was a highly contagious and deadly disease caused by the variola virus.
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I heard that smallpox was a really bad illness back in the day.
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Smallpox was no joke, it could really mess you up.
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The spread of rumors in our office was like a smallpox outbreak, it just wouldn't stop.