noun
a change of circumstances or fortune, typically one that is unwelcome or unpleasant
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The company had to adapt to the vicissitudes of the market in order to stay competitive.
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Life is full of ups and downs, or as some may say, vicissitudes.
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Dealing with the vicissitudes of relationships can be tough, but it's all part of the journey.
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The vicissitudes of fate can sometimes lead us down unexpected paths.