noun
a state of low spirits or loss of hope
verb
to become dejected or disheartened
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After receiving the rejection letter, he fell into a state of despond and withdrew from social activities.
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She was feeling despond after failing her driving test for the third time.
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I can't believe he's still desponding over that breakup from two years ago.
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The dark clouds of despond hung heavy over the small village as they struggled to rebuild after the natural disaster.