verb
To cause someone to feel isolated or estranged.
adjective
Feeling isolated or estranged.
adverb
In a manner that causes someone to feel isolated or estranged.
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The new policies implemented by the company have alienated many long-time employees.
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I feel alienated from my friends ever since I moved to a different city.
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She's been acting so strange lately, like she's totally alienated from reality.
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The artist's unique style alienated some traditional art critics, but gained a strong following among younger audiences.